Chen-Kung Chou

PhD. Molecular Biology, The Albert Einstein College of Medicine

Research

  1. Molecular mechanism of insulin action.
  2. Growth control and signal transduction pathway on human hepatoma cells.

publication  (2001-2005) :

  1. Liu MA, Huang AM, Chou CK, Liaw GJ, Wu CW.(2001)  Utilization of Drosophila eye to probe the functions of two mammalian serine/threonine kinases, Snk and HsHPK. J Biomed Sci. 8:270-7.

  2. Tsao N, Luh TY, Chou CK, Wu JJ, Lin YS, Lei HY. (2001)   Inhibition of group A streptococcus infection by carboxyfullerene. Antimicrob Agents Chemother. 45: 1788-93.

  3. Tu LC, Chou CK, Chen HC, Yeh SF.(2001)   Protein kinase C-mediated tyrosine phosphorylation of paxillin and focal adhesion kinase requires cytoskeletal integrity and is uncoupled to mitogen-activated protein kinase activation in human hepatoma cells. J Biomed Sci. 8:184-90.

  4. Lin AM, Fang SF, Lin SZ, Chou CK, Luh TY, Ho LT. (2002)  Local carboxyfullerene protects cortical infarction in rat brain. Neurosci Res. 43:317-21.

  5. Tsao N, Luh TY, Chou CK, Chang TY, Wu JJ, Liu CC, Lei HY.(2002)     In vitro action of carboxyfullerene. J Antimicrob Chemother. 49:641-9. 

  6. Chiu AW, Huang YL, Huan SK, Wang YC, Ju JP, Chen MF, Chou CK. (2002)   Potential molecular marker for detecting transitional cell carcinoma. Urology. 60:181-5.

  7. Tsou AP, Yang CW, Huang CY, Yu CT, Lee YC, Chang CW, Chen BR, Chung YF, Fann MJ, Chi CW, Chiu JH, Chou CK. (2003)  Identification of a novel cell cycle regulated gene, HURP, overexpressed in human hepatocellular carcinoma. Oncogene. 22: 298-307. 

  8. Chien CY, Liu WK, Chou CK, Su JY. (2003)   The A20-binding protein ABIN-2 exerts unexpected function in mediating transcriptional coactivation. FEBS Lett. 543:55-60.

  9. Liu WK, Chien CY, Chou CK, Su JY.(2003)   An LKB1-Interacting Protein Negatively Regulates TNFalpha-Induced NF-kappaB Activation. J Biomed Sci. 10: 242-52.

  10. Tsou AP, Chuang YC, Su JY, Yang CW, Liao YL, Liu WK, Chiu JH, Chou CK. (2003)   Overexpression of a novel imprinted gene, PEG10, in human hepatocellular carcinoma and in regenerating mouse livers. J Biomed Sci. 10:625-35.

  11. Lin YL, Shiao MS, Mettling C, Chou CK. (2003)  Cholesterol requirement of hepatitis B surface antigen (HBsAg) secretion. Virology. 314:253-60.

  12. Huang HL, Fang LW, Lu SP, Chou CK, Luh TY, Lai MZ. (2003)   DNA-damaging reagents induce apoptosis through reactive oxygen species-dependent Fas aggregation. Oncogene. 22:8168-77.

  13. Lee CH, Ni YH, Chen CC, Chou CK, Chang FH. (2003)  Synergistic effect of polyethylenimine and cationic liposomes in nucleic acid delivery to human cancer cells. Biochim Biophys Acta. 1611:55-62.

  14. Liu WK, Yen PF, Chien CY, Fann MJ, Su JY, Chou CK. (2004)   The inhibitor ABIN-2 disrupts the interaction of receptor-interacting protein with the kinase subunit IKKγ to block activation of the transcription factor NF-κB and potentiate apoptosis. Biochem. J. 378:867-76

  15. Wang YH, Lee EJ, Wu CM, Luh TY, Chou CK, Lei HY. (2004)   Inhibition of middle cerebral artery occlusion-induced focal cerebral ischemia by carboxyfullerene.

    J. Drug Del. Sci. Tech. 14:45-9.

  16. Tu LC, Chou CK, Chen CY, Chang YT, Shen YC, Yeh SF. (2004)  Characterization of the cytotoxic mechanism of Mana-Hox, an analog of manzamine alkaloids. Biochim Biophys Acta. 1672:148-56.

  17. Wang JY, Chiu JH, Tsai TH, Tsou AP, Hu CP, Chi CW, Yeh SF, Lui WY, Wu CW, Chou CK. (2005)   Gene expression profiling predicts liver responses to a herbal remedy after partial hepatectomy in mice.  Int J Mol Med.  Aug;16(2):221-31.

  18. Li Y, Fu L, Yeo H, Zhu JL, Chou CK, Kou YH, Yeh SF, Gullen E, Austin D, Cheng YC. (2005)   Inhibition of hepatitis B virus gene expression and replication by helioxanthin and its derivative. Antivir Chem Chemother.  16(3):193-201.

  19. Yu CT, Hsu JM, Lee YC, Tsou AP, Chou CK, Huang CY. Phosphorylation and stabilization of HURP by Aurora-A: implication of HURP as a transforming target of Aurora-A. (2005)   Mol Cell Biol.  Jul;25(14):5789-800.

  20. Yang CW, Su JY, Tsou AP, Chau GY, Liu HL, Chen CH, Chien CY, Chou CK. (2005)    Integrative genomics based identification of potential human hepatocarcinogenesis-associated cell cycle regulators: RHAMM as an example. Biochem Biophys Res Commun.  May 6;330(2):489-97.

  21. Wu JC, Chen TY, Yu CT, Tsai SJ, Hsu JM, Tang MJ, Chou CK, Lin WJ, Yuan CJ, Huang CY. (2005)    Identification of V23RalA-Ser194 as a critical mediator for Aurora-A-induced cellular motility and transformation by small pool expression screening. J Biol Chem.  Mar 11;280(10):9013-22.

  22. Yang CW, Hsiao CF, Chou CK. (2005)     Evaluation of experimental designs for two-color cDNA microarrays. J Comput Biol. 2005 Nov;12(9):1202-20.